The renoprotective effect of oral Tadalafil pretreatment on ischemia/reperfusion injury in rats
Acta cir. bras
; Acta cir. bras;32(2): 90-97, Feb. 2017. tab, graf
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| ID: biblio-837678
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ABSTRACT
Abstract Purpose:
To evaluate the effect of tadalafil in renal ischemia/reperfusion (I/R) injury in ratsMethods:
Group I/R saline rats (n=6) were subjected to 45 minutes of left renal ischemia and treated with saline; the I/R tadalafil rats (n=6) received oral 10mg/kg tadalafil microemulsion one hour before ischemia. In both groups, 8 hours after ischemia, laboratory analysis were performedResults:
Better tissue perfusion was lower in ischemic left/kidney than in right/kidney in saline group, suggesting reduced kidney clearance. Fluorescence in left/kidneys of tadalafil treated rats was lower than in right/kidneys (difference not significant). The fluorescence signal intensity in kidneys of tadafil treated rats was higher than in saline rats. TNF-α levels were significantly lower in I/R tadalafil group rats compared to I/R saline group (154±10.3 vs 391.3±12.3), as well as IL-1β (163.4±13.2 vs 279±11.5pg/dL), and IL-6 (122.9±8.1 vs 173.7±6.3 respectively; p=0.0001). Urea, creatinine and C-reactive protein were significantly lower in tadafil treated rats then in saline groupConclusion:
Tadalafil therapy decreased the expression of circulating pro-inflammatory cytokines in a renal I/R rodent model, while improving kidney function proofs.Mots clés
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Vasodilatateurs
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Lésion d'ischémie-reperfusion
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Tadalafil
/
Rein
Limites du sujet:
Animals
langue:
En
Texte intégral:
Acta Cir Bras
/
Acta cir. bras
/
Acta cir. bras. (Online)
/
Acta cirúrgica brasileira (Impresso)
Thème du journal:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Année:
2017
Type:
Article