Innate immunity and effector and regulatory mechanisms involved in allergic contact dermatitis
An. bras. dermatol
; 93(2): 242-250, Mar.-Apr. 2018. tab, graf
Article
Dans En
| LILACS
| ID: biblio-887186
Responsable en Bibliothèque :
BR1.1
ABSTRACT
Abstract Skin's innate immunity is the initial activator of immune response mechanisms, influencing the development of adaptive immunity. Some contact allergens are detected by Toll-like receptors (TLRs) and inflammasome NLR3. Keratinocytes participate in innate immunity and, in addition to functioning as an anatomical barrier, secrete cytokines, such as TNF, IL-1β, and IL-18, contributing to the development of Allergic Contact Dermatitis. Dendritic cells recognize and process antigenic peptides into T cells. Neutrophils cause pro-inflammatory reactions, mast cells induce migration/maturation of skin DCs, the natural killer cells have natural cytotoxic capacity, the γδ T cells favor contact with hapten during the sensitization phase, and the innate lymphoid cells act in the early stages by secreting cytokines, as well as act in inflammation and tissue homeostasis. The antigen-specific inflammation is mediated by T cells, and each subtype of T cells (Th1/Tc1, Th2/Tc2, and Th17/Tc17) activates resident skin cells, thus contributing to inflammation. Skin's regulatory T cells have a strong ability to inhibit the proliferation of hapten-specific T cells, acting at the end of the Allergic Contact Dermatitis response and in the control of systemic immune responses. In this review, we report how cutaneous innate immunity is the first line of defense and focus its role in the activation of the adaptive immune response, with effector response induction and its regulation.
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Peau
/
Lymphocytes T
/
Eczéma de contact allergique
/
Immunité innée
Limites du sujet:
Humans
langue:
En
Texte intégral:
An. bras. dermatol
Thème du journal:
DERMATOLOGIA
Année:
2018
Type:
Article