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Using mesenchymal stem cells as a therapy for bone regeneration and repairing
Shao, Jin; Zhang, Weiwei; Yang, Tieyi.
Affiliation
  • Shao, Jin; Second Military Medical University. Shanghai Pudong New Area Gongli Hospital. Department of Orthopaedics. Shanghai. CN
  • Zhang, Weiwei; Shanghai Jiao Tong University. School of Medicine. Ren Ji Hospital. Renji-Med X Clinical Stem Cell Research Center. Shanghai. CN
  • Yang, Tieyi; Second Military Medical University. Shanghai Pudong New Area Gongli Hospital. Department of Orthopaedics. Shanghai. CN
Biol. Res ; 48: 1-7, 2015. ilus
Article de En | LILACS | ID: biblio-950826
Bibliothèque responsable: CL1.1
ABSTRACT
Bone is a unique tissue which could regenerate completely after injury rather than heal itself with a scar. Compared with other tissues the difference is that, during bone repairing and regeneration, after the inflammatory phase the mesenchymal stem cells (MSCs) are recruited to the injury site and differentiate into either chondroblasts or osteoblasts precursors, leading to bone repairing and regeneration. Besides these two precursors, the MSCs can also differentiate into adipocyte precursors, skeletal muscle precursors and some other mesodermal cells. With this multiline-age potentiality, the MSCs are probably used to cure bone injury and other woundings in the near future. Here we will introduce the recent developments in understanding the mechanism of MSCs action in bone regeneration and repairing.
Sujet(s)
Mots clés

Texte intégral: 1 Indice: LILACS Sujet Principal: Ostéogenèse / Régénération osseuse / Différenciation cellulaire / Chondrogenèse / Transplantation de cellules souches mésenchymateuses / Cellules souches mésenchymateuses Limites du sujet: Animals / Humans langue: En Texte intégral: Biol. Res Thème du journal: BIOLOGIA Année: 2015 Type: Article

Texte intégral: 1 Indice: LILACS Sujet Principal: Ostéogenèse / Régénération osseuse / Différenciation cellulaire / Chondrogenèse / Transplantation de cellules souches mésenchymateuses / Cellules souches mésenchymateuses Limites du sujet: Animals / Humans langue: En Texte intégral: Biol. Res Thème du journal: BIOLOGIA Année: 2015 Type: Article