Down-Regulation of NFkB, Bax,TGF-β, Smad-2mRNA expression in the Livers of Carbon Tetrachloride Treated Rats using Different Natural Antioxidants
Braz. arch. biol. technol
; Braz. arch. biol. technol;59: e16150553, 2016. tab, graf
Article
de En
| LILACS
| ID: biblio-951368
Bibliothèque responsable:
BR1.1
ABSTRACT
The objective of this study is to examine whether silymarin alone or in combination with chlorogenic acid and/ or melatonin plays a modulatory role against apoptotic damage in rats liver induced by of CCl4. The present work revealed that CCl4 induced elevation of in Bax, Smad, TGF-β and NFkBhepatic mRNA expression, administration of silymarin alone down regulates these expressions. Treatment with chlorogenic acid and/ or melatonin along with silymarin produced best results in this concern. Bcl-2 expression was down regulated by CCl4 whereas concurrent treatment of chlorogenic acid and/ or melatonin along with silymarin increased this expression. On conclusion, the use of chlorogenic acid and/ or melatonin potentiates the anti-apoptotic action of silymarin.
Texte intégral:
1
Indice:
LILACS
langue:
En
Texte intégral:
Braz. arch. biol. technol
Thème du journal:
BIOLOGIA
Année:
2016
Type:
Article