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Down-Regulation of NFkB, Bax,TGF-β, Smad-2mRNA expression in the Livers of Carbon Tetrachloride Treated Rats using Different Natural Antioxidants
Al-Rasheed, Nouf Mohamed; Fadda, Laila Mohamed; Al-Rasheed, Nawal Mohamed; Ali, Hanaa Mahmoud; Yacoub, Hazar Ibrahim.
Affiliation
  • Al-Rasheed, Nouf Mohamed; King Saud University. Faculty of Pharmacy. Pharmacology Department. Riyadh. SA
  • Fadda, Laila Mohamed; King Saud University. Faculty of Pharmacy. Pharmacology Department. Riyadh. SA
  • Al-Rasheed, Nawal Mohamed; King Saud University. Faculty of Pharmacy. Pharmacology Department. Riyadh. SA
  • Ali, Hanaa Mahmoud; National Research Center. Depatment of Genetics and Cytology. EG
  • Yacoub, Hazar Ibrahim; King Saud University. Faculty of Pharmacy. Pharmacology Department. Riyadh. SA
Braz. arch. biol. technol ; Braz. arch. biol. technol;59: e16150553, 2016. tab, graf
Article de En | LILACS | ID: biblio-951368
Bibliothèque responsable: BR1.1
ABSTRACT
The objective of this study is to examine whether silymarin alone or in combination with chlorogenic acid and/ or melatonin plays a modulatory role against apoptotic damage in rats liver induced by of CCl4. The present work revealed that CCl4 induced elevation of in Bax, Smad, TGF-β and NFkBhepatic mRNA expression, administration of silymarin alone down regulates these expressions. Treatment with chlorogenic acid and/ or melatonin along with silymarin produced best results in this concern. Bcl-2 expression was down regulated by CCl4 whereas concurrent treatment of chlorogenic acid and/ or melatonin along with silymarin increased this expression. On conclusion, the use of chlorogenic acid and/ or melatonin potentiates the anti-apoptotic action of silymarin.
Mots clés

Texte intégral: 1 Indice: LILACS langue: En Texte intégral: Braz. arch. biol. technol Thème du journal: BIOLOGIA Année: 2016 Type: Article

Texte intégral: 1 Indice: LILACS langue: En Texte intégral: Braz. arch. biol. technol Thème du journal: BIOLOGIA Année: 2016 Type: Article