[Diazinon alters sex hormones, Interferon-gamma, Interleukin-4 and 10 in male Wistar rats]
Journal of Gorgan University of Medical Sciences. 2014; 16 (1): 22-28
Dans Fa
| IMEMR
| ID: emr-157569
Responsable en Bibliothèque :
EMRO
ABSTRACT
Agricultural toxins including organochlorine and organophosphorus families cause damages in the various tissues in humans. Diazinon is a non-systemic organophosphate insecticide. This study was carried out to determine the effect of Diazinon on sex hormone, interferon gamma, interleukin-4 and 10 in male rats. In this experimental study 24 adult male Wistar rats were randomly allocated into four groups. Three experimental groups were received Diazinon 5 days per week for one month at 0.3, 3 and 30 mg/kg/bw intraperitoneally, while controls received nothing. Seven days after the last injection, blood samples were obtained and the serum testosterone, FSH, LH, interferon gamma, interleukin-4 and interleukin-10 were measured. Serum level of Interleukin-10 significantly increased in experimental group [30 mg/kg/bw of Diazinon] compared to controls [P<0.05]. Serum level of Interleukin-10 significantly decreased in 0.3 mg/kg/bw and 3mg/kg/bw of Diazinon groups compared to controls [P<0.05]. Interleukin-4 level was only significant in the group receiving 30 mg/kg/bw of Diazinon [P<0.05]. Reduction in interferongamma level was not significant between control and experimental groups. FSH significantly reduced in the three experimental groups in comparison with controls [P<0.05]. Testosterone level was significantly increased in experimental groups compared to control [P<0.05]. Diazinon increases interleukin-10 and testosterone and reduces FSH hormone in the rat
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Indice:
IMEMR
Sujet Principal:
Testostérone
/
Répartition aléatoire
/
Interféron gamma
/
Interleukine-10
/
Rat Wistar
/
Hormone folliculostimulante humaine
Type d'étude:
Clinical_trials
Limites du sujet:
Animals
langue:
Fa
Texte intégral:
J. Gorgan Univ. Med. Sci.
Année:
2014