[Comparison of the intranasal and intraperitoneal injection of MPTP on density of dark neurons in pars compacta of substantia nigra in animal model of Parkinson's disease]

ABSTRACT

Background and Objective: Parkinson disease [PD] is the second most common neurologic disorder that results following degeneration of dopaminergic neurons in the pars compacta of substintia nigra [SNc]. The 1-methyl-1,2,3,6-tetrahydropiridine [MPTP] is a chemical neurotoxin that widely used in animal models of PD. This study was carried out to evaluate the numerical density of dark neurons [DNs] in the SNc in mice subjected to intraperitoneal and intranasal injection of different doses of MPTP