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Role of Family History of Neoplastic Disorders in 100 Patients with Primary Breast Cancer
MJIH-Medical Journal of the Iranian Hospital. 2001; 3 (2): 15-19
Dans En | IMEMR | ID: emr-57789
Responsable en Bibliothèque : EMRO
ABSTRACT
To find whether the family history of neoplasia is a risk factor for breast cancer [BC] in Iran, 100 patients with primary BC were studied. The mean +/- SD of age of the patients was 50 +/- 11 years. In 52% of them left and in 48% right breast was involved. The most frequent pathologic classification was infiltrating ductal carcinoma [IDC]. Tumour size ranged between 0.4 to 6 centimeters. Sixty two% of the subjects had axillary lymph node involvement, and 42% had family history of at least one neoplastic disorder, excluding breast cancers in their pedigrees. The total number of neoplasias was 108 in which BC 27%, colon, uterus, and leukaemia, each 7% were among the more frequent cancers in the pedigrees, and among 29 cases with BC, 19 pedigrees had just one case of BC. The origin of neoplasia was more maternal, with maternal/paternal ratio of 34/6. Comparative study using 100 healthy control subjects, revealed a strong association between a family history of any neoplasia and occurrence of breast cancer in family [crude OR = 7.63 with P = 0.0001; in cases 42 out of 100 had family history of neoplasia versus 9 out of 100 in controls]. Further studies needed to evaluate the role of family history of neoplastic disorders for the risk of developing BC
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Indice: IMEMR Sujet Principal: Tumeurs du sein / Santé de la famille / Facteurs de risque / Prédisposition génétique à une maladie / Recueil de l'anamnèse Limites du sujet: Female / Humans langue: En Texte intégral: Med. J. Iran. Hosp. Année: 2001
Recherche sur Google
Indice: IMEMR Sujet Principal: Tumeurs du sein / Santé de la famille / Facteurs de risque / Prédisposition génétique à une maladie / Recueil de l'anamnèse Limites du sujet: Female / Humans langue: En Texte intégral: Med. J. Iran. Hosp. Année: 2001