Does plasma ANP participate in natriuresis induced by alpha-MSH?
Braz. j. med. biol. res
; 30(4): 459-63, Apr. 1997. tab, graf
Article
Dans En
| LILACS
| ID: lil-191383
Responsable en Bibliothèque :
BR1.1
ABSTRACT
Alpha-Melanocyte-stimulating hormone (alpha-MSH;0.6 and 3 nmol) microinjected into the anteroventral region of the third ventricle (AV3V) induced a significant increase in diuresis without modifying natriuresis or kaliuresis. Intraperitoneal (ip) injection of alpha-MSH (3 and 9.6 nmol) induced a significant increase urinary sodium, potassium and water excretion. Intraperitoneal (3 and 4.8 nmol) or iv (3 and 9.6 nmol) administration of alpha-MSH did not induce any significant changes in plasma atrial natriuretic peptide (ANP), suggesting that the natriuresis, kaliuresis and diuresis induced by the systemic action of alpha-MSH can be dissociated from the increase in plasma ANP. These preliminary results suggest that alpha-MSH may be involved in a gamma-MSH-independent mechanism of regulation of hydromineral metabolism.
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Hormone mélanotrope alpha
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Ventricules cérébraux
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Facteur atrial natriurétique
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Diurèse
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Natriurèse
Limites du sujet:
Animals
langue:
En
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
BIOLOGIA
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MEDICINA
Année:
1997
Type:
Article
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Congress and conference
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Project document