Enterotoxigenicidad de campylobacter jejuni subsp. jejuni y su relación con aumento de AMPc y alteración electrolítica en el intestino de ratas / The relationship of campylobacter jejuni subsp. jejuni enterotoxigenicity and the increase of cAMP and electrolytic alterations in the rat intestine
Rev. méd. Chile
; 126(8): 919-23, ago. 1998. tab
Article
de Es
| LILACS
| ID: lil-232937
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RESUMO
Background:
Small intestine alterations produced by the enterotoxigenic capacity of Campylobacter jejuni subsp. jejuni are similar to the hydric, electrolytic and pathological changes caused by choleraic and thermolabile Escherichia coli toxins.Aim:
To study the enterotoxigenic capacity of 4 strains of Campylobacter jejuni subsp. jejuni using the intestinal loop model. Material andmethods:
Rat intestinal loops were inoculated with culture filtrates of the four strains. Enterotoxigenicity was assessed by fluid accumulation, the increase in Na+ and Cl- in the loop fluid, and cAMP increases in loop tissues. An enterotoxigenic Escherichia coil strain and sterile Brucella both were used as positive and negative controls, respectively.Results:
The filtrates of two strains produced fluid accumulation in the loops, significantly increased Na+ and Cl - secretion to the intestinal lumen and increased tissue cAMP levels.Conclusions:
Some strains of Campylobacter jejuni subsp. jejuni are able to show enterotoxigenicity in vivo, increasing cAMP levels in the intestinal cells and altering electrolyte exchange mechanisms
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Indice:
LILACS
Sujet Principal:
Campylobacter jejuni
/
Entérotoxines
Limites du sujet:
Animals
langue:
Es
Texte intégral:
Rev Med Chil
/
Rev. méd. Chile
/
Rev. méd. Chile (En línea)
/
Revista médica de Chile
Thème du journal:
MEDICINA
Année:
1998
Type:
Article
/
Project document