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Biodistribution studies of bee venom and spider toxin using radiotracers
Yonamine, C. M; Costa, H; Silva, J. A. A; Muramoto, E; Rogero, J. R; Troncone, L. R. P; Camillo, M. A. P.
Affiliation
  • Yonamine, C. M; Instituto de Pesquisas Energéticas e Nucleares. Centro de Biologia Molecular. São Paulo. BR
  • Costa, H; Instituto de Pesquisas Energéticas e Nucleares. Centro de Biologia Molecular. São Paulo. BR
  • Silva, J. A. A; Instituto de Pesquisas Energéticas e Nucleares. Centro de Biologia Molecular. São Paulo. BR
  • Muramoto, E; Instituto de Pesquisas Energéticas e Nucleares. Centro de Biologia Molecular. São Paulo. BR
  • Rogero, J. R; Instituto de Pesquisas Energéticas e Nucleares. Centro de Biologia Molecular. São Paulo. BR
  • Troncone, L. R. P; Instituto Butantan. Laboratório de Farmacologia. São Paulo. BR
  • Camillo, M. A. P; Instituto de Pesquisas Energéticas e Nucleares. Centro de Biologia Molecular. São Paulo. BR
J. venom. anim. toxins incl. trop. dis ; J. venom. anim. toxins incl. trop. dis;11(1): 39-50, jan.-abr. 2005. tab, graf
Article de En | LILACS, SES-SP, VETINDEX | ID: lil-396699
Bibliothèque responsable: BR68.1
RESUMO
The use of radiotracers allows the understanding of the bioavailability process, biodistribution, and kinetics of any molecule labelled with an isotope, which does not alter the molecule's biological properties. In this work, technetium-99m and iodine-125 were chosen as radiotracers for biodistribution studies in mice using bee (Apis mellifera) venom and a toxin (PnTX2-6) from the Brazilian "armed" spider (Phoneutria nigriventer) venom. Incorporated radioactivity was measured in the blood, brain, heart, lung, liver, kidney, adrenal gland, spleen, stomach, testicle, intestine, muscle, and thyroid gland. Results provided the blood kinetic parameter, and different organs distribution rates.(AU)
Sujet(s)
Mots clés

Texte intégral: 1 Indice: LILACS Sujet Principal: Venins d'araignée / Venins d'abeille / Abeilles Limites du sujet: Animals langue: En Texte intégral: J. venom. anim. toxins incl. trop. dis Thème du journal: TOXICOLOGIA Année: 2005 Type: Article

Texte intégral: 1 Indice: LILACS Sujet Principal: Venins d'araignée / Venins d'abeille / Abeilles Limites du sujet: Animals langue: En Texte intégral: J. venom. anim. toxins incl. trop. dis Thème du journal: TOXICOLOGIA Année: 2005 Type: Article