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The cell wall of Paracoccidioides brasiliensis: insights from its transcriptome
Tomazett, P. K; Cruz, A. H; Bonfim, S. M; Soares, C. M; Pereira, M.
Affiliation
  • Tomazett, P. K; Universidade Federal de Goiás. Laboratório de Biologia Molecular. Goiânia. BR
  • Cruz, A. H; Universidade Federal de Goiás. Laboratório de Biologia Molecular. Goiânia. BR
  • Bonfim, S. M; Universidade Federal de Goiás. Laboratório de Biologia Molecular. Goiânia. BR
  • Soares, C. M; Universidade Federal de Goiás. Laboratório de Biologia Molecular. Goiânia. BR
  • Pereira, M; Universidade Federal de Goiás. Laboratório de Biologia Molecular. Goiânia. BR
Genet. mol. res. (Online) ; Genet. mol. res. (Online);4(2): 309-325, 30 jun. 2005. tab, ilus
Article de En | LILACS | ID: lil-445285
Bibliothèque responsable: BR1.1
ABSTRACT
The cell wall of a human pathogenic fungus is in contact with the host, serves as a barrier against host defense mechanisms and harbors most fungal antigens. In addition, cell wall biosynthesis pathways have been recognized as essential to viability and as specific drug targets. Paracoccidioides brasiliensis is a dimorphic fungus that presents mycelium morphology in the free environment and causes infection in a yeast form. The morphogenetic conversion is correlated with changes in the cell wall composition, organization and structure. Based on transcriptome analysis, the enzymes involved in the biosynthesis and remodeling of cell wall polysaccharides, as well as several cell wall-associated molecules of P. brasiliensis, were identified and addressed in further detail.
Sujet(s)
Mots clés
Texte intégral: 1 Indice: LILACS Sujet Principal: Paracoccidioides / Transcription génétique / Paroi cellulaire / Étiquettes de séquences exprimées / Mycelium Limites du sujet: Humans Pays comme sujet: America do sul / Brasil langue: En Texte intégral: Genet. mol. res. (Online) Thème du journal: BIOLOGIA MOLECULAR / GENETICA Année: 2005 Type: Article
Texte intégral: 1 Indice: LILACS Sujet Principal: Paracoccidioides / Transcription génétique / Paroi cellulaire / Étiquettes de séquences exprimées / Mycelium Limites du sujet: Humans Pays comme sujet: America do sul / Brasil langue: En Texte intégral: Genet. mol. res. (Online) Thème du journal: BIOLOGIA MOLECULAR / GENETICA Année: 2005 Type: Article