Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
Mem. Inst. Oswaldo Cruz
; 109(7): 948-951, 11/2014. tab, graf
Article
Dans En
| LILACS
| ID: lil-728801
Responsable en Bibliothèque :
BR1.1
ABSTRACT
The molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the molecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a similar genetic variability between in vitro CQ-resistant and sensitive phenotypes of P. vivax parasites. However, our studies identified two loci (MS8 and MSP1-B10) that could be used to discriminate between both CQ-susceptible phenotypes among P. vivax isolates in vitro. These preliminary data suggest that microsatellites may be used to identify and to monitor the spread of P. vivax-resistance around the world.
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Plasmodium vivax
/
Variation génétique
/
Résistance aux substances
/
Chloroquine
/
ADN des protozoaires
Type d'étude:
Clinical_trials
Limites du sujet:
Humans
Pays comme sujet:
America do sul
/
Brasil
langue:
En
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
MEDICINA TROPICAL
/
PARASITOLOGIA
Année:
2014
Type:
Article