Medication-related osteonecrosis of the jaw. Introduction of a new modified experimental model
Acta cir. bras
; 31(5): 308-313, May 2016. tab, graf
Article
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| ID: lil-783798
Responsable en Bibliothèque :
BR1.1
ABSTRACT
ABSTRACT PURPOSE:
To evaluate a modified experimental model for medication-related osteonecrosis of the jaw (MRONJ) through the upper right central incisor extraction followed by intravenous bisphosphonate administration.METHODS:
Forty five rats underwent the upper right central incisor tooth extraction were divided in 2 groups Group I - experimental group, 30 rats received an intravenous administration protocol of zoledronic acid 35μg/kg into the tail vein every two weeks, totalizing four administrations, during eight weeks of administration, previously the extraction, and Group II - control group, 15 rats didn't received any medication before extraction. The groups were subdivided in postoperative periods 14/28/42 days. Clinical analysis and microtomography were performed to verify the presence of osteonecrosis. In addition, descritive histological analysis of hematoxylin-eosin stained sections was performed to evaluate the presence of osteonecrosis or necrotic foci.RESULTS:
Twelve (40%) rats, from experimental group, showed clinical signs of MRONJ (p=0.005), however, all samples showed imaginologic findings like osteolysis and loss of integrity of the cellular walls (p≤0.001). Microscopic evaluation revealed osteonecrosis areas with microbial colonies and inflammatory infiltrate (p≤0.001). In the control group, all animals presented the chronology of a normal wound healing.CONCLUSIONS:
The presence of medication-related osteonecrosis of the jaw after maxillary central incisor extraction in rats. This new experimental model may be considered an option for the study of MRONJ.
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Modèles animaux
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Diphosphonates
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Ostéonécrose de la mâchoire associée aux biphosphonates
/
Imidazoles
Type d'étude:
Guideline
/
Prognostic_studies
Limites du sujet:
Animals
langue:
En
Texte intégral:
Acta cir. bras
Thème du journal:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Année:
2016
Type:
Article