Congenital adrenal hyperplasia: experience at Calcutta.
Indian Pediatr
; 1992 Aug; 29(8): 1013-8
Article
Dans En
| IMSEAR
| ID: sea-10199
ABSTRACT
Eight patients (7 females, 1 male) with congenital adrenal hyperplasia (CAH), were seen over a 24-month period beginning from March 1988. Seven patients had 21 hydroxylase (21-OH) deficiency while one had 11 beta hydroxylase deficiency. Of the 7 patients with 21-OH deficiency, 3 were of the salt losing (SL-CAH), and 4 were of the non-salt losing (NSL-CAH) type. The patients with NSL-CAH were diagnosed by their elevated 17-hydroxyprogesterone (17-OHP) levels. The 3 cases with SL-CAH were diagnosed on the basis of ambiguous external genitalia, typical electrolyte picture, normal female internal genitalia, sex chromatin and response to steroids. In one patient post-ACTH 17 OHP was alter measured. All 3 patients with SL-CAH were assigned the male sex. Sex reassignment was advised for two children; one accepted the advice and the child is doing well; one family did not accept sex reassignment and the child died. One patient died due to non-availability of fludrocortisone. Six patients are under follow-up. All are doing well except one patient with NSL-CAH who started treatment late. We conclude that a high index of suspicion, early diagnosis and meticulous patient education are the key features of successful management of CAH in India.
Texte intégral:
1
Indice:
IMSEAR
Sujet Principal:
Aberrations des chromosomes sexuels
/
Chromosomes humains de la paire 6
/
Femelle
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Humains
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Mâle
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Bétaméthasone
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Dexaméthasone
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Steroid 21-hydroxylase
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Caractères sexuels
/
Clitoris
Type d'étude:
Screening_studies
Pays comme sujet:
Asia
langue:
En
Texte intégral:
Indian Pediatr
Année:
1992
Type:
Article