Recombination in human leukocyte antigen region in two Asian Indian families.
Indian J Hum Genet
; 2012 Jan; 18(1): 109-111
Article
Dans En
| IMSEAR
| ID: sea-139454
ABSTRACT
BACKGROUND:
Recombination (crossing over) may generate novel haplotypes that can be beneficial to a population against recently introduced pathogens. It may lead to the generation of new alleles. SETTINGS ANDDESIGN:
A prospective study at a tertiary care centre.AIM:
To report two rare cases of crossing over in HLA region. MATERIALS ANDMETHODS:
Tissue-typing was done by sequence specific primers (SSP) for DR locus and by both SSP and serology for Class I which was reconfirmed on fresh samples.RESULTS:
In one patient crossing over had taken place in the region of A locus resulting in inheritance of A*01 instead of expected A*11. In second family crossing over had taken place in region of DRB1 locus and the sibling inherited DRB1*08 instead of DRB1*10.CONCLUSIONS:
Possibility of recombination must be considered when interpreting implausible tissue-typing results of families worked up for BMT.
Texte intégral:
1
Indice:
IMSEAR
Sujet Principal:
Recombinaison génétique
/
Humains
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Famille
/
Asiatiques
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Antigènes d'histocompatibilité
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Antigènes HLA
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Inde
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Complexe majeur d'histocompatibilité
Type d'étude:
Observational_studies
Pays comme sujet:
Asia
langue:
En
Texte intégral:
Indian J Hum Genet
Année:
2012
Type:
Article