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Curative efficacy of norfloxacin in falciparum malaria.
Article de En | IMSEAR | ID: sea-22516
Fifteen patients of uncomplicated falciparum malaria from Delhi were treated with norfloxacin (10 with 400 mg, 5 with 800 mg, both twice daily) for 3 days and the response was measured according to the WHO extended in vivo test criteria. The lower dose produced S response in two, RII response in five and RIII response in three patients, while the higher dose produced S response in four and RI response in one patient. In patients with S or RI response, the parasite clearance time was 68.6 +/- 9.1 h the defervescence time being 48 h. Thus, norfloxacin did reveal in vivo activity in falciparum malaria, but a dose of 400 mg twice daily proved to be curative only in a small percentage of cases and not consistently. Nausea and bitter taste were the only side effects noted in two patients.
Sujet(s)
Texte intégral: 1 Indice: IMSEAR Sujet Principal: Récidive / Femelle / Humains / Mâle / Calendrier d'administration des médicaments / Norfloxacine / Chloroquine / Adolescent / Paludisme à Plasmodium falciparum / Adulte langue: En Année: 1993 Type: Article
Texte intégral: 1 Indice: IMSEAR Sujet Principal: Récidive / Femelle / Humains / Mâle / Calendrier d'administration des médicaments / Norfloxacine / Chloroquine / Adolescent / Paludisme à Plasmodium falciparum / Adulte langue: En Année: 1993 Type: Article