Curative efficacy of norfloxacin in falciparum malaria.
Article
de En
| IMSEAR
| ID: sea-22516
Fifteen patients of uncomplicated falciparum malaria from Delhi were treated with norfloxacin (10 with 400 mg, 5 with 800 mg, both twice daily) for 3 days and the response was measured according to the WHO extended in vivo test criteria. The lower dose produced S response in two, RII response in five and RIII response in three patients, while the higher dose produced S response in four and RI response in one patient. In patients with S or RI response, the parasite clearance time was 68.6 +/- 9.1 h the defervescence time being 48 h. Thus, norfloxacin did reveal in vivo activity in falciparum malaria, but a dose of 400 mg twice daily proved to be curative only in a small percentage of cases and not consistently. Nausea and bitter taste were the only side effects noted in two patients.
Texte intégral:
1
Indice:
IMSEAR
Sujet Principal:
Récidive
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Femelle
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Humains
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Mâle
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Calendrier d'administration des médicaments
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Norfloxacine
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Chloroquine
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Adolescent
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Paludisme à Plasmodium falciparum
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Adulte
langue:
En
Année:
1993
Type:
Article