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Tetany in kala azar patients treated with paromomycin.
Article de En | IMSEAR | ID: sea-23980
Paromomycin, an aminoglycoside, is known to cause several side effects like nephrotoxicity and ototoxicity like other aminoglycosides but tetany has not been reported. Three cases of tetany were detected in the patients of kala-azar treated with paromomycin. They were promptly treated with intravenous 10 per cent calcium gluconate and tetany was relieved immediately and treatment with paromomycin continued with oral calcium supplement. After completion of 21 days treatment with paromomycin patients' splenic aspirates were free of parasites. Paromomycin may cause temporary tubular damage leading to calcium wasting in urine and hypocalcaemia resulting in tetany. Prompt detection of symptoms and intravenous calcium gluconate treatment promptly reverse the situation.
Sujet(s)
Texte intégral: 1 Indice: IMSEAR Sujet Principal: Tétanie / Femelle / Humains / Mâle / Paromomycine / Essais contrôlés randomisés comme sujet / Enfant / Enfant d'âge préscolaire / Calcium / Adolescent Type d'étude: Clinical_trials langue: En Année: 2008 Type: Article
Texte intégral: 1 Indice: IMSEAR Sujet Principal: Tétanie / Femelle / Humains / Mâle / Paromomycine / Essais contrôlés randomisés comme sujet / Enfant / Enfant d'âge préscolaire / Calcium / Adolescent Type d'étude: Clinical_trials langue: En Année: 2008 Type: Article