Induction of rifampicin metabolism during treatment of tuberculous patients with daily and fully intermittent regimens containing the drug.
Indian J Chest Dis Allied Sci
; 1989 Oct-Dec; 31(4): 251-7
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| ID: sea-29882
ABSTRACT
Self-induction of rifampicin metabolism during daily and intermittent chemotherapy was studied by monitoring the changes in the serum half-life of the drug over a 4-week period in patients with pulmonary tuberculosis. Rifampicin 450 mg was administered to 8 patients who received treatment daily, 7 on thrice-weekly and 7 others on twice-weekly treatment. Serum half-life was computed from concentrations of the drug determined at 3, 4 1/2 and 6 hours after drug administration, on admission and at 1, 2 and 4 weeks after start of treatment. In the daily series, the mean serum half-life decreased from 4.9 hours on admission to 3.6 hours at 1 week (P = 0.02), and treatment beyond this had no further effect. In the thrice-weekly series, maximal induction was observed at the 2nd week, the mean values on admission and at 2 weeks being 5.8 and 3.7 hours, respectively (P less than 0.01). In the twice-weekly series, maximal induction was observed only at the 4th week, the mean values on admission and at 4 weeks being 4.9 and 3.7 hours, respectively (P less than 0.01). Serum activity of gamma glutamyl transferase was not found to be a suitable in vivo marker to monitor induction of the hepatic microsomal enzymes as no significant changes were observed in the activity of this enzyme in any of the 3 series during the 4-week period.
Texte intégral:
1
Indice:
IMSEAR
Sujet Principal:
Pyrazinamide
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Rifampicine
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Tuberculose pulmonaire
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Humains
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Calendrier d'administration des médicaments
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Microsomes du foie
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Induction enzymatique
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Association de médicaments
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Éthambutol
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Gamma-Glutamyltransferase
langue:
En
Texte intégral:
Indian J Chest Dis Allied Sci
Année:
1989
Type:
Article