Changes in erythrocyte glucose-6-phosphate dehydrogenase (G6PD) and reduced glutathione (GSH) activities in the development of senile and diabetic cataracts.
Southeast Asian J Trop Med Public Health
; 2008 Jul; 39(4): 731-6
Article
Dans En
| IMSEAR
| ID: sea-35099
ABSTRACT
Oxidative and osmotic stress have been implicated in the pathogenesis of cataracts. Reactive oxygen intermediates (ROI) mediate peroxidation of membrane lipids and cause irreversible damage to lens proteins. The purpose of this study was to assess the changes in erythrocyte glucose- 6-phosphate dehydrogenase enzyme (G6PD) and reduced glutathione (GSH) levels in the development of senile and diabetic cataracts. The activity of erythrocyte G6PD and the concentration of GSH were measured to assess changes in oxidation-reduction status. The oxidation-reduction status of 26 non-diabetic non-cataract (control) subjects were compared with 24 diabetic non-cataract, 30 diabetic cataract and 28 non-diabetic cataract subjects. The results revealed that the GSH and G6PD levels of the subjects with senile cataracts were significantly lower than the subjects without cataracts. The present study reveals the risk of developing senile cataracts is associated with decreased levels of erythrocyte G6PD and GSH. In the formation of diabetic cataracts an adequate supply of NADPH (G6PD activity) is essential to produce osmotically active sorbitol in the lens.
Texte intégral:
1
Indice:
IMSEAR
Sujet Principal:
Oxydoréduction
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Cataracte
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Sujet âgé de 80 ans ou plus
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Sujet âgé
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Humains
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Vieillissement
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Études cas-témoins
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Facteurs de risque
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Complications du diabète
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Diabète
Type d'étude:
Etiology_studies
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Observational_studies
Limites du sujet:
Aged80
langue:
En
Texte intégral:
Southeast Asian J Trop Med Public Health
Année:
2008
Type:
Article