Prevalence of high--risk human papillomavirus infections in women with benign cervical cytology: a hospital based study from North India.
Indian J Cancer
; 2006 Jul-Sep; 43(3): 110-6
Article
Dans En
| IMSEAR
| ID: sea-50990
ABSTRACT
INTRODUCTION:
Cervical cancer is the commonest cancer among Indian women. High-risk human papillomavirus (HPV) detection holds the potential to be used as a tool to identify women, at risk for subsequent development of cervical cancer. There is a pressing need for identifying prevalence of asymptomatic cervical HPV infection in the local population.OBJECTIVE:
To determine the prevalence of high-risk HPV DNA in women with benign cervical cytology. MATERIALS ANDMETHODS:
Women visiting the gynecology outpatient with varied complaints were subjected to Pap smear. Four hundred and seventy two samples were subjected to polymerase chain reaction, using consensus primers for low and high-risk HPV (types 6, 11, 16, 18, 31 and 33). The samples that were positive for HPV DNA were subsequently assessed for high-risk consensus primers, types 16, 18, 31 and 33 as well as for HPV type 16 and 18.RESULTS:
One hundred and seventy four (36.8%) women tested positive for HPV DNA. Thirty nine (8.2%) of the entire cohort tested positive for high-risk HPV. Fifteen samples were positive for type 16, 22 for type 18 and two for both types 16 and 18. A statistically higher prevalence of high-risk HPV was observed in poorly educated and rural groups. No association of HPV prevalence was noted with age, parity and age at marriage.CONCLUSION:
The study generates epidemiological data of prevalence of sub-clinical HPV in the women visiting a tertiary care institute as well as peripheral health centres. The data generated will be useful for laying guidelines for mass screening of HPV, treatment and prophylaxis in the local population.
Texte intégral:
1
Indice:
IMSEAR
Sujet Principal:
Frottis vaginaux
/
Sujet âgé
/
Femelle
/
Humains
/
ADN viral
/
Réaction de polymérisation en chaîne
/
Prévalence
/
Facteurs de risque
/
Adulte
/
Infections à papillomavirus
Type d'étude:
Clinical_trials
/
Etiology_studies
/
Guideline
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Pays comme sujet:
Asia
langue:
En
Texte intégral:
Indian J Cancer
Année:
2006
Type:
Article