Assessment of viability by normal mouse foot-pad and bacillary ATP bioluminescence assay in multibacillary cases treated with an MDT regimen using conventional as well as newer drugs like minocycline and ofloxacin.
Indian J Lepr
; 2000 Oct-Dec; 72(4): 437-42
Article
Dans En
| IMSEAR
| ID: sea-55473
ABSTRACT
The therapeutic effect of a drug regimen of conventional drugs as well as newer drugs like ofloxacin and minocycline in smear-positive multibacillary (MB) leprosy cases was assessed by mouse foot-pad and ATP bioluminiscence methods. Biopsies were taken before starting treatment and after one year of treatment. They were processed for viability assessment by normal mouse foot-pad inoculation and bacillary ATP assay techniques. The test regimen was quite effective in its anti-bacterial effect as it was found to result in loss of bacillary viability in all the cases, as assessed by both methods.
Texte intégral:
1
Indice:
IMSEAR
Sujet Principal:
Humains
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Adénosine triphosphate
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Résultat thérapeutique
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Pied
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Antilépreux
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Lèpre
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Mesures de luminescence
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Animaux
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Souris
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Mycobacterium leprae
langue:
En
Texte intégral:
Indian J Lepr
Thème du journal:
Tropical Medicine
Année:
2000
Type:
Article