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Effect of short and long-term exposure to diesel exhaust on sensitivity of guinea pig tracheal preparation to histamine.
Indian J Exp Biol ; 1997 Aug; 35(8): 837-40
Article de En | IMSEAR | ID: sea-60477
Single exposure, to diesel exhaust (1 part exhaust diluted by 5 parts of clean air) reduced EC50 of histamine indicating hyperresponsiveness of the receptors in trachea of exposed guinea pigs. In contrast, following repeated exposure for 7, 14 or 21 days (15 min/day), EC50 was progressively increased indicating the possibility of down-regulated histamine receptors. Further, simultaneous significant increase in histamine levels (bioassayed on guinea pig ileum) in bronchial airway lavage fluid supports the aforementioned hypothesis. The change in lung/body weight ratio and suspended particulate matter deposited on filters followed the same temporal pattern as EC50. The findings are suggestive of differential effects of diesel exhaust on airway depending upon the duration of exposure.
Sujet(s)
Texte intégral: 1 Indice: IMSEAR Sujet Principal: Facteurs temps / Trachée / Emissions des véhicules / Femelle / Mâle / Histamine / Polluants atmosphériques / Cochons d'Inde / Animaux langue: En Texte intégral: Indian J Exp Biol Année: 1997 Type: Article
Texte intégral: 1 Indice: IMSEAR Sujet Principal: Facteurs temps / Trachée / Emissions des véhicules / Femelle / Mâle / Histamine / Polluants atmosphériques / Cochons d'Inde / Animaux langue: En Texte intégral: Indian J Exp Biol Année: 1997 Type: Article