Role of kappa opioid receptors during stress responsiveness in rats.
Indian J Exp Biol
; 1993 Feb; 31(2): 116-9
Article
de En
| IMSEAR
| ID: sea-63017
Effects of kappa opioid agonist, ketocyclazocine (KCZ) and its antagonist, M(r) 2266, were evaluated on some stress responses in rats. KCZ (1 or 10 mg/kg, ip) dose-dependently attenuated cold restraint stress (CRS)-induced gastric ulcer formation. Similar gastric cytoprotection was also seen with KCZ (1 or 10 micrograms/rat, icv). Pretreatment of rats with M(r) 2266 (0.3 mg/kg, ip) clearly antagonized the ulceroprotective effects of both ip and icv KCZ. KCZ effects on the gastric mucosa during CRS were also reduced by naltrexone (5 mg/kg, ip) pretreatment. KCZ (1 or 10 mg/kg, ip) also attenuated the plasma corticosterone response to CRS and these effects were blocked by M(r) 2266 (0.3 mg/kg) pretreatment. These results indicate kappa opioid receptor involvement during stress reactions and also suggest possible opioidergic interactions during CRS.
Texte intégral:
1
Indice:
IMSEAR
Sujet Principal:
Rats
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Ulcère gastrique
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Stress physiologique
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Benzomorphanes
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Mâle
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Corticostérone
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3-Cyclopropyl-6-éthyl-8-hydroxy-11-méthyl-3,4,5,6-tétrahydro-2,6-méthano-3-benzazocin-1(2H)-one
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Rat Wistar
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Récepteur kappa
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Animaux
langue:
En
Texte intégral:
Indian J Exp Biol
Année:
1993
Type:
Article