Altered oxidant-antioxidant status in non-obese men with moderate essential hypertension.
Indian J Med Sci
; 2007 Jun; 61(6): 326-31
Article
Dans En
| IMSEAR
| ID: sea-68521
ABSTRACT
BACKGROUND:
Although a wide number of experimental evidences are available regarding oxidant-antioxidant disturbance in hypertension, clinical data supporting it is lacking in men in early stages of hypertension.AIMS:
The objective of the study was to evaluate oxidative status and antioxidant activities in males with stage I essential hypertension. MATERIALS ANDMETHODS:
Thirty hypertensives and 21 normotensives were included in the study. Protein carbonyl, reduced glutathione, glutathione peroxidase, catalase and fasting glucose were assessed in both the groups. STATISTICALANALYSIS:
Results were analyzed by student's 't' test and linear regression analysis test.RESULTS:
Plasma protein carbonyl and glutathione peroxidase were significantly increased and catalase and GSH were significantly reduced in the hypertensive group compared to normotensive subjects. There was a significant negative correlation between glutathione peroxidase and catalase in the test group.CONCLUSIONS:
The data from the present study indicates an alteration in oxidant-antioxidant status in non-obese men in early stages of essential hypertension.
Texte intégral:
1
Indice:
IMSEAR
Sujet Principal:
Indice de gravité de la maladie
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Glycémie
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Humains
/
Mâle
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Catalase
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Modèles linéaires
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Stress oxydatif
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Adulte
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Carbonylation des protéines
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Glutathion
langue:
En
Texte intégral:
Indian J Med Sci
Année:
2007
Type:
Article