Useful markers for differential diagnosis of oncocytoma, chromophobe renal cell carcinoma and conventional renal cell carcinoma.
Indian J Pathol Microbiol
; 2008 Apr-Jun; 51(2): 167-71
Article
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| IMSEAR
| ID: sea-73881
ABSTRACT
Renal oncocytoma, conventional RCC (granular cell type) and chromophobe RCC have different prognosis. Sometimes differentiation between them is difficult in HandE slides. In a 5-year study of 128 renal tumors, we selected 76 cases [30 conventional RCC (CRCC), 16 papillary RCC, 21 chromophobe RCC (ChRCC), 8 oncocytoma, 1 collecting duct carcinoma (cdc)] and staining with Hale's colloidal iron, CK7, CK8, CK18, CK19, CK20, Vimentin, EMA, CD10 and RCC marker were done. No significant difference was seen between renal tumor subtypes with CK8, CK18, CK19, CK20 and EMA. The most useful markers were Vimentin, CK7, CD10, RCC marker and Hale's colloidal iron. Hale's colloidal iron staining with diffuse reticular fine cytoplasmic pattern was present in ChRCCs, but was absent in other subtypes and oncocytomas. Vimentin, CK7, CD10, RCC marker and Hale's colloidal iron can be used for the differential diagnosis of problematic epithelial tumors of kidney (CRCC, ChRCC and oncocytoma) - i.e. ChRCC Vimentin, CD10 and RCC marker - negative, CK7 - positive and positive diffuse fine reticular cytoplasmic pattern of Hale's colloidal iron; oncocytoma Vimentin, CK7, RCC marker and CD10 - negative and Hale's colloidal iron - negative; CRCC CK7 - negative, Vimentin, CD10 and RCC marker - positive and Hale's colloidal iron - negative.
Texte intégral:
1
Indice:
IMSEAR
Sujet Principal:
Vimentine
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Sujet âgé de 80 ans ou plus
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Sujet âgé
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Femelle
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Humains
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Mâle
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Néphrocarcinome
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Néprilysine
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Marqueurs biologiques tumoraux
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Adénome oxyphile
Type d'étude:
Diagnostic_studies
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Prognostic_studies
Limites du sujet:
Aged80
langue:
En
Texte intégral:
Indian J Pathol Microbiol
Année:
2008
Type:
Article