Neoadjuvant chemotherapy before surgery of hepatoblastoma.
Indian J Pediatr
; 2006 Aug; 73(8): 735-7
Article
de En
| IMSEAR
| ID: sea-83554
Though surgical resection is the main stay of treatment for childhood hepatoblastoma (HB), many are unsuitable for radical surgery at diagnosis due to extensive intrahepatic and/or extra hepatic disease. We report experience in five patients of HB from a single institution (2001-2005) with preoperative Neoadjuvant chemotherapy (NACT) followed by surgery. Three patients received cisplatin, doxorubicin; and two cisplatin / vincristine /5-fluorouracil. All showed more than 50% reduction in tumor size confirmed by CT scan. Hepatic resection R0 was performed in all. There was no chemotherapy related toxicity nor post surgical morbidity or mortality. All are disease free at median follow up of 4 years. NACT produces adequate down staging of the HB with acceptable toxicity. Though cisplatin with doxorubicin produced good results, new protocol with cisplatin, vincristine and 5FU is promising without cardiotoxicity.
Texte intégral:
1
Indice:
IMSEAR
Sujet Principal:
Humains
/
Mâle
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Protocoles de polychimiothérapie antinéoplasique
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Enfant d'âge préscolaire
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Hépatoblastome
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Traitement néoadjuvant
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Hépatectomie
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Nourrisson
/
Tumeurs du foie
Type d'étude:
Guideline
langue:
En
Texte intégral:
Indian J Pediatr
Année:
2006
Type:
Article