Evaluation of naked eye single tube red cell osmotic fragility test in detecting beta-thalassemia trait.
Indian Pediatr
; 1991 May; 28(5): 469-72
Article
Dans En
| IMSEAR
| ID: sea-9061
ABSTRACT
The Naked Eye Single Tube Red Cell Osmotic Fragility Test (NESTROFT) was applied to 4 groups of subjects:
(i) Normal; (ii) Proven beta-thalassemia trait carriers; (iii) Iron deficiency anemia; and (iv) other hemoglobinopathies, to evaluate its effectiveness as a screening test for beta-thalassemia minor. The test was successful in detecting 105/110 subjects with beta-thalassemia trait. The sensitivity of the test was 95.5% and specificity was 87%. The predictive value of the positive test was 70.5% and that of the negative test was 98.3%. NESTROFT was also positive in 9/17 subjects with HbS trait, in 3/3 subjects with HbD trait and in 1/1 subjects with HbE trait. The test proved to be simple, cheap, easy to perform and adaptable for field surveys, coming close to an ideal screening test for beta-thalassemia minor.
Texte intégral:
1
Indice:
IMSEAR
Sujet Principal:
Fragilité osmotique
/
Thalassémie
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Humains
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Enfant
/
Valeur prédictive des tests
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Erreurs de diagnostic
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Numération des érythrocytes
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Érythrocytes
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Tests hématologiques
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Dépistage des porteurs génétiques
Type d'étude:
Clinical_trials
/
Diagnostic_studies
Pays comme sujet:
Asia
langue:
En
Texte intégral:
Indian Pediatr
Année:
1991
Type:
Article