Analysis of chylemia and its impact on blood product quality / 中国输血杂志

ABSTRACT

【Objective】 To analyze the causes of chylemia, explore the effects of varying degrees of chylemia on subsequent blood products and the countermeasures. 【Methods】 The information of blood donors in the Central Blood Station of Xinjiang Production and Construction Corps from January 2018 to July 2022 were analyzed retrospectively, and the causes of fatty blood discarding was analyzed in terms of gender, age and times of donation. The effects of chylemia of control group, mild group, moderate group and severe group and corresponding gender and age on the hemolysis rate of suspended red blood cells(RBCs) at the end of storage and residual amount of methylene blue in the inactivated plasma were discussed. 【Results】 The incidence of chylemia in males(0.93%,84/9 047) was much higher than that in females(0.24%,9/3 781) (P<0. 05). The hemolysis rates of WBC-free suspended RBCs of mild, moderate and severe chylemia group at the end of storage(0. 19±0.08,0.28±0.06,0.66±0.25) were higher than that in control group(0.08±0.03), in males significantly higher than those in females(0.08±0.03 vs 0.06±0.02,0.21±0.09 vs 0.15±0.04,0.30±0.05 vs 0.24±0.07), in the age group of 18-30 years significantly lower than those in 31-41 years(0.07±0.02 vs 0.09±0.03) and ≥41 years(0.07±0.02 vs 0.09±0.03), P <0.05. The residual methylene blue in plasma with viral inactivation prepared from mild and moderate chylemia was significantly higher than that in control group(0.12±0.02,0.18±0.06 vs 0.06±0.02) (P<0.05). 【Conclusion】 Chylemia shall be monitored during the whole process of blood collection, and coutermeasures shall be taken to decrease the effects of chylemia on blood quality.