Effect of nilotinib on pregnancy outcome in female patients with chronic myeloid leukemia / 中华血液学杂志
Chinese Journal of Hematology
; (12): 986-989, 2019.
Article
de Zh
| WPRIM
| ID: wpr-1012112
Bibliothèque responsable:
WPRO
ABSTRACT
Objective: To observe the pregnancy outcome among patients with chronic myeloid leukemia (CML) treated with Nilotinib (NIL) . Methods: Clinical data of pregnancy delivery in CML patients treated with NIL from March 2015 to January 2019 were retrospectively collected. Results: A total of 11 patients were recruited with median pregnancy age 28 (25-40) years. The median duration of NIL treatment before pregnancy was 34 (3-48) months. There were 12 pregnancies, included 2 planned ones and 10 (83.3%) unplanned. In the 10 unplanned patients, 9 (90.0%) received NIL 600 mg/d. The median exposure time were 4 (4-7) weeks. In eight patients with delivery outcomes, 5 cases had well-developed babies, 2 had spontaneous abortion and 1 case with an baby of syndactyly deformity, whose mother was exposed to NIL 600 mg/d for 7 weeks in the early trimester of pregnancy. Seven infants were 4 boys and 3 girls with the median height at birth 50 (41-54) cm and median weight 3.2 (3.0-4.6) kg. They all grew with a normal pattern and well developed. Now the median age is 19 (4-41) months. The disease status during 12 pregnancies included 3 cases in CMR, 2 cases in MR(4.0), 3 cases in MMR, 4 cases not acquiring MMR. The median time of drug discontinuation was 35 (15-36) weeks during pregnancy. No patient lost CHR during this period. Conclusions: Female CML patients exposed to NIL 600 mg/d for 4 weeks in early pregnancy can give birth to normal babies, but there is still a risk of spontaneous abortion and congenital malformations.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pyrimidines
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Issue de la grossesse
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Leucémie myéloïde chronique BCR-ABL positive
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Études rétrospectives
Limites du sujet:
Adult
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Child, preschool
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Female
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Humans
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Infant
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Male
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Pregnancy
langue:
Zh
Texte intégral:
Chinese Journal of Hematology
Année:
2019
Type:
Article