Association between the polymorphism of aldosterone synthase gene promoter-344T/C and preeclampsia in Qinghai Province / 解剖学报
Acta Anatomica Sinica
; (6): 306-310, 2021.
Article
de Zh
| WPRIM
| ID: wpr-1015481
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WPRO
ABSTRACT
Objective To investigate the relationship between preeclampsia (PE) and polymorphism of aldosterone synthase gene (CYP11B2) promoter region-344T/C in Qinghai Province. Methods A total of 120 PE subjects and 155 normal pregnancy subjects were studied. The genotype of CYP11B2 was analyzed by polymerase chain reaction fragment length polymorphism (PCR-RFLP). The mutation was confirmed by sequencing. Results The frequencies of CYP11B2 TT, CT and CC genotype in the PE group were 43.0%, 45.6%, and 11.4%, and in the control group were 51.0%, 45.1%, and 3.9%, respectively. There was difference in frequency distribution of CYP11B2 genotype between the PE and control groups. The frequency of C allele in the PE group was higher than the control group (χ
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WPRIM
langue:
Zh
Texte intégral:
Acta Anatomica Sinica
Année:
2021
Type:
Article