Mechanism of Bmal1 Involved in Irritable Bowel Syndrome via TPH1-5-HT Signaling Pathway in Enterochromaffin Cells / 胃肠病学
Chinese Journal of Gastroenterology
; (12): 321-327, 2022.
Article
de Zh
| WPRIM
| ID: wpr-1016104
Bibliothèque responsable:
WPRO
ABSTRACT
Background: Disrupted circadian rhythms have been associated with the development of irritable bowel syndrome (IBS). In some IBS patients, the symptoms may present with circadian fluctuations. Enterochromaffin cells (EC cells) and tryptophan hydroxylase 1 (TPH1) - 5 - hydroxytryptamine (5 - HT) signaling pathway are currently recognized as the key pathophysiological mechanism of IBS. Aims: To explore whether Bmal1, the core circadian clock gene, is involved in the occurrence of IBS by regulating TPH1-5-HT signaling pathway in EC cells. Methods: Normal Sprague-Dawley (SD) rats and IBS-model SD rats, as well as wild type (WT) and intestine-specific Bmal1 knockout (Bmal1
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Indice:
WPRIM
langue:
Zh
Texte intégral:
Chinese Journal of Gastroenterology
Année:
2022
Type:
Article