Progress of ORMDL3 involved in the pathogenesis of bronchial asthma in children / 国际儿科学杂志

ABSTRACT

Bronchial asthma is a common chronic airway inflammatory disease in children, and its pathogenesis is closely related to genetic and environmental factors.A number of clinical epidemiological investigations have found that the single nucleotide polymorphisms variation of orosomucoid 1-like protein 3(ORMDL3)gene is closely related to the incidence of childhood asthma, but the mechanism of ORMDL3′s involvement in the occurrence and development of childhood asthma remains unclear.In recent years, researchers have explored the biological function of ORMDL3, and found that ORMDL3 may be involved in bronchial epithelial cell inflammation, epithelial cell barrier damage and T cell immune imbalance through endoplasmic reticulum stress and sphingoid metabolic response, and may also mediate the mechanism of early respiratory tract infection and possible wheezing in infants and young children.Therefore, this paper reviews the latest progress of ORMDL3′s involvement in the pathogenesis of bronchial asthma in children.