Effects of self-made Ningxin Huoxue Qutan Decoction combined with Aspirin on serum cyclophilin A level after percutaneous coronary intervention in acute coronary syndrome / 国际中医中药杂志

ABSTRACT

Objective:To explore the effects of self-made Ningxin Huoxue Qutan Decoction combined with Aspirin on the level of serum cyclophilin A (CyPA) in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI).Methods:Randomized controlled trial. A total of 142 patients in the hospital from February 2017 to January 2022 were selected as the participants by randomized controlled trial design, and they were divided into the two groups by the random number table method, with 71 in each group. The control group was given oral administration of Aspirin while the observation group was treated with self-made Ningxin Huoxue Qutan Decoction on the basis of the control group. Both groups were treated for 8 weeks. The left ventricular ejection fraction (LVEF), left ventricular end-systolic volume index (LVESVI) and wall motion score index (WMSI) were measured by color ultrasonic diagnostic instrument before and after treatment. The levels of serum angiopoietin-like protein 2 (Angptl2), hypersensitive C-reactive protein (hs-CRP), MMP-9, CyPA and myeloperoxidase (MPO) were detected by ELISA. Serum endothelin-1 (ET-1), MDA and SOD levels were detected by radioimmunoassay. Nitrate reductase was used to detect NO level, and the clinical efficacy was evaluated.Results:The total effective rate in observation group was 92.96% (66/71) and that in control group was 80.28% (57/71) ( χ2=4.92, P=0.027). After treatment, the LVEF in observation group was significantly higher than that of the control group ( t=2.19, P<0.05) while the LVESVI was significantly lower than that of the control group ( t=3.13, P<0.01). The levels of serum hs-CRP, MMP-9, CyPA, MDA and Angptl2 were significantly lower than those in the control group ( t=2.44, 2.20, 2.08, 2.10, 2.35, P<0.05), and the SOD activity was significantly higher than that of the control group ( t=2.66, P<0.05), and the level of NO was significantly higher than that of the control group ( t=2.66, P<0.05). Conclusion:Self-made Ningxin Huoxue Qutan Decoction combined with Aspirin for patients with ACS after PCI can reduce the level of serum CyPA, improve the cardiac function and vascular endothelial function, inhibit the body' s inflammatory stress response and enhance the clinical efficacy.