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Detection of germline variants in pancreatic cancer by next-generation sequencing and correlation analysis of clinical factors / 复旦学报(医学版)
Article de Zh | WPRIM | ID: wpr-1019574
Bibliothèque responsable: WPRO
ABSTRACT
Objective To investigate the rate of germline variants in patients with pancreatic cancer and clinical characteristics related with germline variants.Methods A total of 271 patients diagnosed with pancreatic cancer were enrolled in this study.Germline variants of 21 tumor susceptibility genes were detected by next-generation sequencing,and the relationship between germline variants and clinical factors such as age of onset,family history and personal history was analyzed.Results The rate of germline P/LP variants was 6.3%in unselected pancreatic cancer patients,but was high as 17.1%in genetic high-risk group patients(those with a family or personal history of cancer,or early-onset).Genes with higher frequency of germline variants in pancreatic cancer patients were PALB2,BRCA2,and ATM.Conclusion The rate of germline variants in overall pancreatic cancer patients is not high,but it increases significantly in genetic high-risk group,proving the importance of clinical factors in the screening of hereditary pancreatic cancer.
Mots clés
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Fudan University Journal of Medical Sciences Année: 2024 Type: Article
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Fudan University Journal of Medical Sciences Année: 2024 Type: Article