Review in Treatment of Inflammatory Diseases with Flavonoids Based on NLRP3 Inflammasome / 世界科学技术-中医药现代化

ABSTRACT

NLRP3(NLR family pyrin domain containing 3)is the core of the inflammatory response,and its excessive activation involves the development of various diseases,including neurodegenerative diseases,autoimmune diseases and metabolic disorders,etc.In recent years,it has been found that natural flavonoids can extensively inhibit the diseases caused by NLRP3 inflammation overactivation via various mechanisms,including resistance to oxidative stress,promotion of autophagy,stabilization of mitochondrial function,adjustment ion channels and inhibition of NLRP3 inflammation composition.In this paper,we reviewed the relevant latest research reports,compiled the types and pathogenesis of diseases caused by excessive activation of NLRP3 inflammation,and summarized the mechanisms on the prevention and treatment of various diseases by inhibiting NLRP3 inflammation with natural flavonoids.This review provides new ideas for the development of new drugs using flavonoid components in the prevention and treatment of NLRP3 inflammatory-related diseases.