Efficacy and safety of anlotinib monotherapy and combinated therapy in the treatment of advanced pheo-chromocytoma/paraganglioma / 实用医学杂志
The Journal of Practical Medicine
; (24): 3106-3110, 2023.
Article
de Zh
| WPRIM
| ID: wpr-1020662
Bibliothèque responsable:
WPRO
ABSTRACT
Objective To evaluate the efficacy and safety of anlotinib monotherapy and combined therapy in patients with advanced pheochromocytoma/paraganglioma.Methods Nine patients with advanced pheochromo-cytoma/paraganglioma(PPGL)who were admitted to the Department of Urology,Sun Yat-sen University Cancer Center from January 2018 to June 2023 were collected.Patients were divided into four groups according to different treatments:anlotinib monotherapy group(3 patients),anlotinib combined with PD-1 monoclonal antibody immuno-therapy group(3 patients),anlotinib combined with immunotherapy and chemotherapy group(2 patients),and anlotinib combined with chemotherapy group(1 patients).The effectiveness and safety of different treatment regiments of anlotinib were analyzed.Results Objective response rate(ORR):(44%),Partial response(PR):(44%),Stable disease(SD):(44%),Progressive disease(PD):(11%),Disease control rate(DCR):(89%).The ORR of 2 patients with SDH gene mutation,SDHB and SDHD respectively,was 100%.Median overall survival time(OS)was 16.3 months(IQR:11.3~21.8 months).Median progression-free survival(PFS)was 16.3 months(IQR:9.8~20.8 months).There were 2 patients with adverse events grade≥3/4,all of which were hypertension.Conclusions Anlotinib monotherapy and combined therapy have preliminary efficacy and manageable safety in the treatment of advanced pheochromocytoma/paraganglioma.
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WPRIM
langue:
Zh
Texte intégral:
The Journal of Practical Medicine
Année:
2023
Type:
Article