A Case of Typhlitis Developed after Chemotherapy with Irinotecan and Cisplatin in a Patient with Small Cell Lung Carcinoma / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
; : 288-291, 2012.
Article
de En
| WPRIM
| ID: wpr-10264
Bibliothèque responsable:
WPRO
ABSTRACT
Typhlitis is a necrotizing colitis that usually occurs in neutropenic patients and develops most often in patients with hematologic malignancies such as leukemia and lymphoma. Typhlitis may proceed to bowel perforation, peritonitis and sepsis, which requires immediate treatment. Irinotecan is a semisynthetic analogue of the natural alkaloid camptothecin which prevents DNA from unwinding by inhibition of topoisomerase I. It is mainly used in colon cancer and small cell lung carcinoma (SCLC), of which the most common adverse effects are gastrointestinal toxicities. To the best of our knowledge, no case of typhlitis after chemotherapy with a standard dose of irinotecan in a solid tumor has been reported in the literature. We, herein, report the first case of typhlitis developed after chemotherapy combining irinotecan and cisplatin in a patient with SCLC.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Péritonite
/
Camptothécine
/
ADN
/
Leucémies
/
Cisplatine
/
Colite
/
Tumeurs du côlon
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ADN topoisomérases de type I
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Sepsie
/
Tumeurs hématologiques
Limites du sujet:
Humans
langue:
En
Texte intégral:
Tuberculosis and Respiratory Diseases
Année:
2012
Type:
Article