Research Progress on O-GLcNAc Glycosylation Modification in Neurodegenerative Diseases / 中山大学学报(医学科学版)

ABSTRACT

O-linked N-acetylglucosamine glycosylation （O-GlcNAcylation） is a protein post- translational protein formed by O-linked acetylglucosamine and serine/threonine residues on intracellular proteins. O-GlcNAc glycosylation modification is ubiquitous in the brain and is closely related to transcription， translation and protein homeostasis. O-GlcNAc glycosylation modification is involved in the occurrence and development of various neurological degenerative diseases， but its regulatory mechanism remains unclear. This paper reviews the relationship between O-GlcNAc glycosylation modification and neurological degenerative diseases.