Study of cognitive impairment in patients with severe stenosis or occlusion of left and right intracranial arteries / 中风与神经疾病杂志

ABSTRACT

@#Objective　Aim to detect the cognitive function impairment early，we studied the effects of severe stenosis or occlusion of left and right intracranial artery，so as to take effective intervention measures in a timely manner. Methods　All patients were chosen from the outpatients and inpatients New Era Stroke Care and Research Institute of PLA Rocket Force Characteristic Medical Center from September 2013 to May 2016，a total number of 242.There were 53 patients in the normal group，15 and 13 patients in left and right intracranial artery severe stenosis or occlusion groups respectively. All patients were assessed for vascular stenosis，screened for 10 points according to the left/right ASPECTS and pc- ASPECTS scores based on 3T-MRI FLAIR sequence，and neuropsychological assessment was performed using the traditional MMSE，MoCA scale and multidimensional psychological assessment system. Results　The scores of MMSE，time orientation and memory of patients with severe stenosis or occlusion of the left intracranial artery were significantly lower than those of normal group（P<0.01，P<0.05，P<0.01）；the scores of word discrimination test were significantly lower in patients with left and right intracranial artery severe stenosis or occlusion than that of normal group （P<0.05）. Conclusion　Cognitive impairment was associated with severe intracranial artery stenosis or occlusion. Severe intracranial artery stenosis or occlusion of the left may be more likely to cause cognitive impairment than the right side. Therefore，it is of great significance to carry out targeted early intervention and treatment for patients with severe intracranial arterial stenosis or occlusion.