Tandem High-Dose Chemotherapy Increases the Risk of Secondary Malignant Neoplasm in Pediatric Solid Tumors / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 642-651, 2024.
Article
Dans En
| WPRIM
| ID: wpr-1042312
Responsable en Bibliothèque :
WPRO
ABSTRACT
Purpose@#This study aimed to investigate the incidence and risk factors for secondary malignant neoplasms (SMN) in pediatric solid tumors, focusing on the effects of tandem high-dose chemotherapy (HDCT). @*Materials and Methods@#Patients (aged 2, 340 cGy, and tandem HDCT were significant risk factors for SMN development. The SMN types varied according to the primary tumor type; carcinoma was the most frequent SMN in brain tumors and neuroblastoma, whereas hematologic malignancy and sarcomas developed more frequently in patients with sarcoma and retinoblastoma, respectively. @*Conclusion@#The cumulative incidence of SMN in pediatric patients with solid tumors was considerably high, especially in patients who underwent tandem HDCT or in those who received RT > 2,340 cGy. Therefore, the treatment intensity should be optimized based on individual risk assessment and the long-term follow-up of pediatric cancer survivors.
Texte intégral:
1
Indice:
WPRIM
langue:
En
Texte intégral:
Cancer Research and Treatment
Année:
2024
Type:
Article