Chromosomal Abnormalities in Myelodysplastic Syndrome with Near-tetraploidy: A Case Report
Laboratory Medicine Online
; : 47-50, 2012.
Article
Dans Ko
| WPRIM
| ID: wpr-106976
Responsable en Bibliothèque :
WPRO
ABSTRACT
Massive hyperdiploidy and tetraploidy are rare cytogenetic abnormalities in myelocytic malignancies, especially in myelodysplastic syndrome (MDS). These abnormalities are known to be associated with leukemogenesis, leukemic transformation and poor prognosis. We report here the first case of MDS with near-tetraploid cytogenetic abnormality in Korea. A 80-yr-old male was diagnosed with refractory anemia with excess blasts-2 (RAEB-2). Bone marrow aspiration smear showed 16% of blasts, which were large sized myeloid blasts with irregular margins and cytoplasmic vacuolation. Cytogenetic analysis of bone marrow cells revealed numercal and structural cytogenetic abnormalities including near-tetraploidy in 8 of 20 metaphases 45,XY,add(1)(p36.1),del(10)(p11.2),del(11)(q13),-12,-16,der(17)t(11;17) (q13;q21),add(20)(q13.1),+mar[8]/85~90,idemx2[cp8]/46,XY[4]. After chemotherapy with decitabine, he showed pancytopenia during follow-up period and died of sepsis 14 months after the diagnosis.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pancytopénie
/
Pronostic
/
Azacitidine
/
Moelle osseuse
/
Syndromes myélodysplasiques
/
Anémie réfractaire
/
Cellules de la moelle osseuse
/
Études de suivi
/
Aberrations des chromosomes
/
Sepsie
Type d'étude:
Observational_studies
/
Prognostic_studies
Limites du sujet:
Humans
/
Male
Pays comme sujet:
Asia
langue:
Ko
Texte intégral:
Laboratory Medicine Online
Année:
2012
Type:
Article