Two Clinical Cases of Anti-Di(b) with Di(a+b-) Phenotypes: Practical Need for Rare Blood Donor Registry Program in Korea

ABSTRACT

Here, we report two cases of identified anti-Di(b) antibodies with rare Di(a+b−) blood types from two different hospitals in Korea. Di(b) mismatched transfusion could cause a hemolytic transfusion reaction. However, it is extremely difficult to find compatible blood for patients with such a rare blood type. In this regard, we concluded that national level rare donor registry program, wherein rare blood types are indexed, needs to be established. Moreover, laboratory medicine specialists at each hospital should encourage donor registration and family testing through education for helping patients with rare blood types. These efforts will help establish a system that guarantees safe blood transfusion for patients.