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Prevalence and Genotype Distribution of Cervical Human Papillomavirus DNA in Korean Women: A Multicenter Study
Article de En | WPRIM | ID: wpr-108864
Bibliothèque responsable: WPRO
ABSTRACT
Background: DNA prevalence and type distribution of human papillomavirus (HPV) varies geographically. We investigated HPV prevalence and type distribution in Korean women using the MyHPV DNA chip testing. Methods: A total of 2,368 women from five regions of the country underwent Pap smear examination and MyHPV chip testing. Results: Overall HPV positivity was 15.8% and 78.4% in women with normal and abnormal cytology, respectively. High-risk HPV infection was strongly correlated with cytological atypia. In women with abnormal cytology, the five most common HPV types were 16, 58, 18, 52, and 56/53, and HPV16 was significantly the most common type in most geographical regions. After HPV16, HPV58, and 52 were the next most frequently detected types. Women with normal cytology, in contrast, showed heterogeneity in HPV type distribution. High-grade intraepithelial lesions infected with HPV16, 18, 31 or 45 are more likely to progress to carcinoma. Conclusions: The HPV chip test can provide useful data regarding HPV positivity and type. The most common HPV type in Korean women with abnormal cytology is HPV16, with HPV58 and 52 being frequently present. Our data may have important implications for vaccination programs and the development of cervical screening.
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Texte intégral: 1 Indice: WPRIM Sujet Principal: Frottis vaginaux / Caractéristiques de la population / ADN / Col de l'utérus / Dépistage de masse / Prévalence / Vaccination / Séquençage par oligonucléotides en batterie / République de Corée / Génotype Type d'étude: Clinical_trials / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limites du sujet: Female / Humans Pays comme sujet: Asia langue: En Texte intégral: Korean Journal of Pathology Année: 2009 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Frottis vaginaux / Caractéristiques de la population / ADN / Col de l'utérus / Dépistage de masse / Prévalence / Vaccination / Séquençage par oligonucléotides en batterie / République de Corée / Génotype Type d'étude: Clinical_trials / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limites du sujet: Female / Humans Pays comme sujet: Asia langue: En Texte intégral: Korean Journal of Pathology Année: 2009 Type: Article