Antifungal Effects of New Synthetic Materials, KAF-200522 and KAF-200522-HCl, on in vitro and in vivo Models / 한국실험동물학회지
Laboratory Animal Research
; : 353-359, 2010.
Article
de Ko
| WPRIM
| ID: wpr-109627
Bibliothèque responsable:
WPRO
ABSTRACT
KAF-200522 and its chloride form, KAF-200522-HCl, were invented in Chemon inc. as new triazole antifungal agents with excellent activities in vivo and in vitro against wide range of fungi. As a result of in vitro susceptibility measurements, 80% minimum inhibitory concentrations (MIC80) of both test articles against Candida albican sp. and Aspergillus fumigatus sp. were below 0.0156 microg/mL, which were over 4,100 times lower than those of fluconazole against fluconazole resistant C. albican sp. and A. fumigatus sp., and were over 16 times lower than those of amphotericin B against above same fungi. Additionally, against representative dermatophytes, Trichophyton sp., the MIC80s of both test articles were below 0.0156 microg/mL which were over 64 times lower than those of fluconazole and amphotericin B. As in vivo antifungal activities in A. fumigatus sp. infected mouse models, KAF-200522 treatment group at 600 mg/kg showed 80% survival rate which was 2 times higher than that of amphotericin B and showed 13.7 days in the mean survival time (MST) which was about 2.1 times higher than that of amphotericin B. But in KAF-200522-HCl treatment groups, all animals were found dead in contrast to 40% survival rate in amphotericin B treatment group, however dose dependent increases in MST was revealed. In conclusion, antifungal activities of KAF-200522 and its mimics, KAF-200522-HCl in vitro and in vivo were confirmed in this study, therefore the potentiality of the present compounds to be developed into new antifungal drug was expected.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Aspergillus fumigatus
/
Trichophyton
/
Candida albicans
/
Tests de sensibilité microbienne
/
Fluconazole
/
Amphotéricine B
/
Taux de survie
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Arthrodermataceae
/
Champignons
/
Antifongiques
Limites du sujet:
Animals
langue:
Ko
Texte intégral:
Laboratory Animal Research
Année:
2010
Type:
Article