Prophylactic Effect of Erythropoietin Injection to Prevent Acute Mountain Sickness: An Open-Label Randomized Controlled Trial
Journal of Korean Medical Science
; : 416-422, 2014.
Article
de En
| WPRIM
| ID: wpr-112003
Bibliothèque responsable:
WPRO
ABSTRACT
This study was performed to evaluate whether increasing hemoglobin before ascent by prophylactic erythropoietin injections prevents acute mountain sickness (AMS). This open-label, randomized, controlled trial involved 39 healthy volunteers with hemoglobin or =3 were present. Immediate descent criteria followed US Army recommendations. Two groups differ in hemoglobin levels on day 29 (15.4+/-1.1 vs 14.2+/-1.0 g/dL, P=0.001). At ABC, erythropoietin group had a significantly lower mean LLS, AMS incidence, and number of subjects who met immediate descent criteria. Multiple logistic regression analysis showed that SaO2<87% and control group, but not hemoglobin<15.0 g/dL, independently predicted satisfaction of immediate descent criteria. Erythropoietin-related adverse effects were not observed. In conclusion, erythropoietin may be an effective prophylaxis for AMS.(Clinical Trial Registry Number; NCT 01665781).
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Oxygène
/
Pression sanguine
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Protéines recombinantes
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Hémoglobines
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Calendrier d'administration des médicaments
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Modèles logistiques
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Odds ratio
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Maladie aigüe
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Incidence
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Enquêtes et questionnaires
Type d'étude:
Clinical_trials
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Etiology_studies
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Guideline
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Incidence_studies
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Prognostic_studies
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Risk_factors_studies
Limites du sujet:
Adult
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Female
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Humans
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Male
langue:
En
Texte intégral:
Journal of Korean Medical Science
Année:
2014
Type:
Article