Effect of Atorvastatin, a HMG-CoA Reductase Inhibitor, in Experimental Colitis in Mice
Korean Journal of Pathology
; : 401-407, 2004.
Article
de En
| WPRIM
| ID: wpr-112678
Bibliothèque responsable:
WPRO
ABSTRACT
BACKGROUND: The statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are approved for cholesterol reduction, and may also be beneficial in the treatment of inflammatory disease. In this study, atorvastatin was tested in experimental colitis, a disease model of inflammatory bowel disease. METHODS: To induce colitis, dextran sodium sulfate (DSS) or trinitrobenzene sulfonic acid (TNBS) were administrated to C57BL/6 or BALB/c mice. Mice were monitored daily for loss of body weight and survival for indicated days. Colon length and histology were examined after sacrifice. RESULTS: The administration of DSS induced marked colonic inflammation and shortening, and resulted in a loss of body weight. DSSinduced colitis was not affected by atorvastatin treatment, but in contrast, the administration of atorvastatin relieved TNBS-induced colitis with a resultant rapid recovery of weight loss and a reduction in colonic length shortening. Histologically, inflammatory cell infiltration in the colonic wall, mucosal ulceration and crypt disruption were also suppressed in atorvastatin treated mice. CONCLUSION: These results suggest that atorvastatin preserves intestinal integrity in colitis, probably via the modulation of Th cell-mediated immune response, in a manner independent of innate immunity.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Oxidoreductases
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Sodium
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Ulcère
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Poids
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Maladies inflammatoires intestinales
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Perte de poids
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Cholestérol
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Dextrane
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Coenzyme A
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Colite
Limites du sujet:
Animals
langue:
En
Texte intégral:
Korean Journal of Pathology
Année:
2004
Type:
Article