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Clinical Significance of MET Gene Copy Number in Patients with Curatively Resected Gastric Cancer / 전남의대학술지
Chonnam Medical Journal ; : 81-85, 2015.
Article de En | WPRIM | ID: wpr-121246
Bibliothèque responsable: WPRO
ABSTRACT
The present study analyzed the prognostic impact of MET gene copy number in patients with curatively resected gastric cancer who received a combination regimen of cisplatin and S-1. The MET gene copy number was analyzed by use of quantitative real-time polymerase chain reaction. From January 2006 to July 2010, 70 tumor samples from 74 patients enrolled in a pilot study were analyzed. According to a cutoff MET gene copy number of > or =2 copies, a high MET gene copy number was observed in 38 patients (54.3%). The characteristics of the 2 groups divided according to MET gene copy number were similar. With a median follow-up duration of 26.4 months (range, 2.6-73.2 months), the estimated 3-year relapse-free survival and overall survival rates were 54.3% and 77.4%, respectively. No significant association was observed between the MET gene copy number and survival in a multivariate analysis. The MET gene copy number investigated in this study was not found to be associated with prognosis in patients with curatively resected gastric cancer.
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Texte intégral: 1 Indice: WPRIM Sujet Principal: Pronostic / Tumeurs de l'estomac / Projets pilotes / Analyse multifactorielle / Taux de survie / Études de suivi / Cisplatine / Traitement médicamenteux adjuvant / Dosage génique / Réaction de polymérisation en chaine en temps réel Type d'étude: Observational_studies / Prognostic_studies Limites du sujet: Humans langue: En Texte intégral: Chonnam Medical Journal Année: 2015 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Pronostic / Tumeurs de l'estomac / Projets pilotes / Analyse multifactorielle / Taux de survie / Études de suivi / Cisplatine / Traitement médicamenteux adjuvant / Dosage génique / Réaction de polymérisation en chaine en temps réel Type d'étude: Observational_studies / Prognostic_studies Limites du sujet: Humans langue: En Texte intégral: Chonnam Medical Journal Année: 2015 Type: Article