Quinolone-resistant Shigella flexneri Isolated in a Patient Who Travelled to India
Annals of Laboratory Medicine
; : 366-369, 2012.
Article
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| ID: wpr-125848
Responsable en Bibliothèque :
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ABSTRACT
We report a recent case in which ciprofloxacin-resistant Shigella flexneri was isolated from a 23-yr-old female patient with a history of travel to India. Prior to her admission to our internal medicine department, she experienced symptoms of high fever and generalized weakness from continuous watery diarrhea that developed midway during the trip. S. flexneri was isolated from the stool culture. Despite initial treatment with ciprofloxacin, the stool cultures continued to show S. flexneri growth. In the susceptibility test for antibiotics of the quinolone family, the isolate showed resistance to ciprofloxacin (minimum inhibitory concentration [MIC], 8 microg/mL), norfloxacin (MIC, 32 microg/mL), ofloxacin (MIC, 8 microg/mL), nalidixic acid (MIC, 256 microg/mL), and intermediate resistance to levofloxacin (MIC, 4 microg/mL). In molecular studies for quinolone resistance related genes, plasmid borne-quinolone resistance genes such as qnrA, qnrB, qnrS, aac(6')-Ib-cr, qepA, and oqxAB were not detected. Two mutations were observed in gyrA (248C-->T, 259G-->A) and 1 mutation in parC (239G-->T). The molecular characteristics of the isolated S. flexneri showed that the isolate was more similar to the strains isolated from the dysentery outbreak in India than those isolated from Korea.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Shigella flexneri
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Protéines bactériennes
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Voyage
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Quinolinone
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Résistance bactérienne aux médicaments
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Dysenterie bacillaire
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Fèces
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Inde
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Antibactériens
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Mutation
Limites du sujet:
Female
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Humans
Pays comme sujet:
Asia
langue:
En
Texte intégral:
Annals of Laboratory Medicine
Année:
2012
Type:
Article