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A Case of P-ANCA-Positive Anti-Glomerular Basement Membrane Antibody Disease / 대한내과학회지
Korean Journal of Medicine ; : 807-812, 2012.
Article de Ko | WPRIM | ID: wpr-126592
Bibliothèque responsable: WPRO
ABSTRACT
Up to 40% of patients with anti-glomerular basement membrane (GBM) disease, which is a rare autoimmune disorder usually manifesting as rapidly progressive glomerulonephritis (RPGN), are positive for circulating anti-neutrophil cytoplasmic antibody (ANCA). Many previous reports showed poor outcomes in these "double-positive" patients. We report a patient with perinuclear (p)-ANCA positive anti-GBM disease who presented with RPGN and required hemodialysis. Plasmapheresis and steroid and cyclophosphamide therapy were initiated following renal biopsy and resulted in normalization of anti-GBM antibody and p-ANCA titers, recovery of renal function, and discontinuation of hemodialysis. This case suggests that aggressive immunosuppression with plasmapheresis in patients who are p-ANCA positive with anti-GBM disease should be considered, even in those with severe renal dysfunction.
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Mots clés
Texte intégral: 1 Indice: WPRIM Sujet Principal: Autoanticorps / Membrane basale / Biopsie / Dialyse rénale / Immunosuppression thérapeutique / Plasmaphérèse / Anticorps anti-cytoplasme des polynucléaires neutrophiles / Maladie des anticorps antimembrane basale glomérulaire / Cyclophosphamide / Glomérulonéphrite Limites du sujet: Humans langue: Ko Texte intégral: Korean Journal of Medicine Année: 2012 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Autoanticorps / Membrane basale / Biopsie / Dialyse rénale / Immunosuppression thérapeutique / Plasmaphérèse / Anticorps anti-cytoplasme des polynucléaires neutrophiles / Maladie des anticorps antimembrane basale glomérulaire / Cyclophosphamide / Glomérulonéphrite Limites du sujet: Humans langue: Ko Texte intégral: Korean Journal of Medicine Année: 2012 Type: Article