Efficacy of Chemotherapy in Patients with Unresectable or Metastatic Pancreatic Acinar Cell Carcinoma: Potentially Improved Efficacy with Oxaliplatin-Containing Regimen / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 759-765, 2017.
Article
Dans En
| WPRIM
| ID: wpr-129235
Responsable en Bibliothèque :
WPRO
ABSTRACT
PURPOSE:
Pancreatic acinar cell carcinoma (ACC) is a rare cancer of the exocrine pancreas. Because of its rare incidence, the efficacy of chemotherapy in this patient population has been largely unknown. Therefore, we retrospectively analyzed the outcomes of patients with advanced pancreatic ACC who received chemotherapy. MATERIALS ANDMETHODS:
Between January 1997 and March 2015, 15 patients with unresectable or metastatic pancreatic ACC who received systemic chemotherapy were identified in Asan Medical Center, Korea.RESULTS:
The median age was 58 years. Eleven and four patients had recurrent/metastatic and locally advanced unresectable disease. The median overall survival in all patients was 20.9 months (95% confidence interval [CI], 15.7 to 26.1). As first-line therapy, intravenous 5-fluorouracil were administered in four patients (27%), gemcitabine in five (33%), gemcitabine plus capecitabine in two (13%), oxaliplatin plus 5-fluorouracil/leucovorin (FOLFOX) in two (13%), and concurrent chemoradiotherapy followed by capecitabine maintenance therapy in two (13%). The objective response rate (ORR) to chemotherapy alone was 23% and the median progression-free survival (PFS) was 5.6 months (95% CI, 2.8 to 8.4). After progression, second-line chemotherapy was administered in eight patients, while four patients received FOLFOX and the other four patients received gemcitabine. The ORR was 38%, and patients administered FOLFOX had significantly better PFS than those administered gemcitabine (median, 6.5 months vs. 1.4 months; p=0.007). The ratio of time to tumor progression (TTP) during first-line chemotherapy to TTP at second-line chemotherapy was significantly higher in patients administered FOLFOX (4.07; range, 0.87 to 8.30) than in those administered gemcitabine (0.12; range, 0.08 to 0.25; p=0.029).CONCLUSION:
Our results suggest that oxaliplatin-containing regimens may have improved activity against pancreatic ACC.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Tumeurs du pancréas
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Incidence
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Études rétrospectives
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Carcinome à cellules acineuses
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Survie sans rechute
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Pancréas exocrine
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Traitement médicamenteux
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Cellules acineuses
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Chimioradiothérapie
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Capécitabine
Type d'étude:
Incidence_studies
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limites du sujet:
Humans
Pays comme sujet:
Asia
langue:
En
Texte intégral:
Cancer Research and Treatment
Année:
2017
Type:
Article